Mechanism of Action:
Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. By inhibiting PDE5, sildenafil increases the levels of cGMP, leading to smooth muscle relaxation and vasodilation, thereby promoting blood flow to the penis and facilitating an erection.
Recommendations for Use:
Sildenafil is typically taken orally, as needed, approximately 30 minutes to 1 hour before sexual activity. It is important to note that sexual stimulation is necessary for sildenafil to be effective. The recommended starting dose for most men is 50 mg, although the dosage may be adjusted based on individual response and tolerance. It is advisable not to take sildenafil more than once a day.
Dosage:
The typical starting dose of sildenafil is 50 mg, taken as needed, approximately 30 minutes to 1 hour before sexual activity. The dosage may be adjusted based on individual response and tolerability, with a maximum recommended dose of 100 mg per day. We encourage you to read more about it on Australian Prescriber.
Precautions:
Before taking sildenafil, it is essential to consult with a healthcare professional, especially if you have underlying medical conditions such as cardiovascular disease, liver or kidney impairment, or a history of priapism (prolonged erection). Additionally, sildenafil should not be used concurrently with nitrates or nitric oxide donors, as this combination can lead to a sudden and severe drop in blood pressure.
Contraindications:
Sildenafil is contraindicated in individuals with a known hypersensitivity to the drug or any of its components. It should not be used in patients who are taking nitrates or nitric oxide donors, as well as those with severe cardiovascular disease, hypotension, or recent stroke or heart attack.
Side Effects:
Common side effects of sildenafil include headache, flushing, dyspepsia, nasal congestion, and visual disturbances. These side effects are usually mild to moderate in severity and transient in nature. However, more serious side effects such as priapism, sudden hearing loss, and vision changes requiring immediate medical attention are rare but possible.
Drug Interactions:
Sildenafil may interact with certain medications, including nitrates, alpha-blockers, antihypertensives, and protease inhibitors. It is important to inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.
Overdose:
In case of sildenafil overdose, seek immediate medical attention. Symptoms of overdose may include severe hypotension, priapism, and visual disturbances.
Storage Conditions:
Sildenafil should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets.
Toxicity and Dependence:
Sildenafil is generally well-tolerated when used as directed. There is no evidence to suggest that sildenafil causes toxicity or dependence when used for the treatment of erectile dysfunction.
To sum it up, sildenafil is an effective and well-tolerated medication for the treatment of erectile dysfunction. However, it is essential to use it responsibly and under the guidance of a healthcare professional to maximize its benefits and minimize the risk of adverse effects.