Mechanism of action:
Dapoxetine works by inhibiting the reuptake of serotonin, a neurotransmitter involved in regulating mood and ejaculation. By increasing serotonin levels in the brain, dapoxetine helps to improve control over ejaculation and extend the time to ejaculation during sexual activity.
Recommendations for use:
Dapoxetine is typically taken orally, as needed, approximately 1 to 3 hours before anticipated sexual activity. It is important to note that dapoxetine should not be used as a daily medication; it is intended for on-demand use only.
Dosage:
The recommended starting dose of dapoxetine is 30 mg, taken as needed before sexual activity. The dosage may be adjusted based on individual response and tolerability, with a maximum recommended dose of 60 mg per day. It is advisable not to take dapoxetine more than once a day.
Precautions:
Before taking dapoxetine, it is important to consult with a healthcare professional, especially if you have underlying medical conditions such as liver or kidney impairment, or a history of psychiatric disorders. Additionally, dapoxetine should not be used concurrently with certain medications, including monoamine oxidase inhibitors (MAOIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or other SSRIs.
Contraindications:
Dapoxetine is contraindicated in men with a known hypersensitivity to the drug or any of its components. It should not be used in patients with significant cardiovascular disease, including heart failure, arrhythmias, or recent myocardial infarction.
Side effects:
Common side effects of dapoxetine include nausea, headache, dizziness, and diarrhea. These side effects are usually mild to moderate in severity and transient in nature. However, more serious side effects such as fainting, seizures, or serotonin syndrome are rare but possible.
Drug interactions:
Dapoxetine may interact with certain medications, including MAOIs, SNRIs, SSRIs, tricyclic antidepressants, and certain antifungal medications. It is important to inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.
Overdose:
In case of dapoxetine overdose, seek immediate medical attention. Symptoms of overdose may include serotonin syndrome, characterized by confusion, agitation, rapid heartbeat, and fever.
Storage conditions:
Dapoxetine should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets.
Toxicity and dependence:
Dapoxetine is generally well-tolerated when used as directed. There is no evidence to suggest that dapoxetine causes toxicity or dependence when used for the treatment of premature ejaculation.