What Is Cialis
First approved by the Therapeutic Goods Administration (TGA) in Australia in the early 2000s, tadalafil has become a trusted solution for millions of men across the country dealing with erectile difficulties. Cialis generic contain tadalafil - the same active ingredient as the brand Cialis, also prescribed for pulmonary arterial hypertension and benign prostatic hyperplasia treatment.
How Does Cialis Work
During sexual arousal, the body releases nitric oxide in the erectile tissue of the penis. This nitric oxide and activates a guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). Higher cGMP levels promote relaxation of the smooth muscle in the corpus cavernosum, and allows increased blood flow into the penis, resulting in an erection.Tadalafil enters this process and inhibits phosphodiesterase type 5 (PDE5), an enzyme that breaks down cGMP. By blocking PDE5, tadalafil helps maintain elevated cGMP levels and prolongs the relaxation of smooth muscle. Cialis effects can last up to 36 hours.
Research published in the Australian Journal of Pharmacy (2018) demonstrated that tadalafil has a higher selectivity for PDE5 compared to other enzymes in the phosphodiesterase family, what explain its relatively lower incidence of side effects compared to other medications in the same class.
For patients with benign prostatic hyperplasia (BPH), tadalafil works through a similar mechanism but targets the smooth muscle of the prostate and bladder. A clinical trial conducted at the University of Sydney (2019) found that daily tadalafil treatment significantly improved urinary symptoms in men with BPH and reduced inflammation in the lower urinary tract.
Cialis Dosage
Tadalafil dosing start on cialis 10mg taken as needed before sexual activity. This dosage can be adjusted up to 20mg or down to 5mg. Cialis in 2.5mg to 5mg dosages may be prescribed for daily intake. Higher dosages such as cialis mg 40 are rarely prescribed for erectile dysfunction in Australia but may be utilized for pulmonary arterial hypertension under specialist supervision. The maximum recommended frequency is once per 24 hours, regardless of the dosage, more frequent use increases the risk of side effects without efficacy improve. Never take a double dose to compensate for a missed one, as this can increase the risk of adverse effects.
Cialis Effect Duration
Most men notice the onset of effects within 30 minutes after taking a dose. Tadalafil's effects can persist for up to 36 hours, which has earned it the nickname "the weekend pill" among Australian. Tadalafil half-life averages about 17.5 hours. For adults under 65, cialis remains active in the system for approximately 36 hours, though some effects may be noticeable up to 48 hours after dosing in certain individuals.When prescribed as a daily medication at lower doses (2.5mg or 5mg), tadalafil maintains a steady state in the bloodstream after about five days of consecutive use.
How To Use Cialis
Take Cialis at least 30 minutes before anticipated sexual activity. The tablet should be swallowed whole with a full glass of water, and should not be crushed or split.Tadalafil can be taken with or without food. Extremely high-fat meals may delay absorption slightly and potentially extend the time until onset of action. Grapefruit and grapefruit juice should be avoided as they can inhibit the enzymes that metabolize tadalafil and lead to higher blood levels increasing risk of side effects.
Side Effects
According to data from the Therapeutic Goods Administration of Australia, most side effects are transient and resolve without intervention:
- Common side effects:
- Headache
- Indigestion or heartburn
- Back pain
- Muscle aches
- Facial flushing
- Nasal congestion
- Nausea
- Uncommon side effects:
- Dizziness
- Blurred vision
- Eyelid swelling
- Eye pain
- Palpitations
- Increased sweating
- Skin rash
- Serious side effects, requiring immediate medical attention:
- Priapism (painful erection lasting longer than 4 hours)
- Loss of vision (NAION)
- Loss of hearing
- Chest pain or irregular heartbeat
- Allergic reactions (hives, difficulty breathing, swelling of face/lips)
If side effects persist or worsen, consult your healthcare provider for potential dosage adjustments or alternative treatments. Never adjust dosage independently without medical guidance.
Cialis and Alcohol
Both cialis and alcohol can lower blood pressure, and when used together, they may cause excessive drops leading to dizziness, headaches, increased heart rate, or fainting. Alcohol consumption can directly counteract tadalafil's effectiveness and reduce blood flow to the penis. Alcohol acts as a depressant on the nervous system and nullify the cialis benefits. For optimal results and safety it is recommended to separate alcohol consumption from tadalafil use.
Cialis Contraindications
Don't use tadalafil if you:
- Take nitrate medications (such as nitroglycerin, isosorbide mononitrate, isosorbide dinitrate) for chest pain or heart conditions
- Use recreational drugs known as "poppers" (amyl nitrite, butyl nitrite)
- Take guanylate cyclase stimulators like riociguat for pulmonary hypertension
- Allergic to tadalafil or any ingredients in the tablet
- Advised by your doctor to refrain from sexual activity due to cardiovascular risk
- Experienced a heart attack or stroke within 3 months
- Suffer from unstable angina or angina during sexual intercourse
- Diagnosed with severe heart failure or uncontrolled irregular heartbeats
- Live with severely low or uncontrolled high blood pressure
- Suffer from retinitis pigmentosa or other inherited eye diseases
- Previously experienced non-arteritic anterior ischemic optic neuropathy (NAION)
- Diagnosed with severe liver impairment or end-stage kidney disease requiring dialysis
Use tadalafil with caution if you have anatomical deformation of the penis (such as Peyronie's disease), conditions that may predispose to priapism (sickle cell anemia, multiple myeloma, leukemia), or active peptic ulceration.
Generic Tadalafil
Cialis Professional
Cialis Professional - tadalafil with sublingual delivery system for faster absorption. Manufactured by Dharam Distributors in India, this version costs AUD $35-45 for 10 tablets.
Cialis Soft
Cialis Soft - generic tadalafil in a chewable tablet form that dissolves more rapidly than conventional pills. Produced by Sunrise Remedies in India, these tablets priced at AUD $40-50 for 10 tablets in Australia.
Cialis Super Active
Cialis Super Active - 20mg of generic tadalafil in a soft gelatin capsule designed for enhanced absorption. Manufactured by RS Laboratories in India, ranges AUD $50-60 per 10 capsules.
Tadalista
Tadalista - generic tadalafil produced by Combitic Global Caplet in India. Available in various strengths from 5mg to 60mg, Tadalista typically costs AUD $30-40.
Vidalista
Vidalista - tadalafil generic tablets manufactured by Centurion Laboratories in India. Available in multiple dosages from 2.5mg to 40mg, it costs AUD $25-35 for 10 tablets (20mg) in Australia.
Tadapox
Tadapox contains 20mg tadalafil and 60mg dapoxetine, designed to address both erectile dysfunction and premature ejaculation. Manufactured by RSM Enterprises in India,Tadapox costs AUD $60-70 for 10 tablets.
Sildalis
Sildalis combines 20mg tadalafil with 100mg sildenafil citrate (the active ingredient in Viagra) to provide dual-mechanism erectile dysfunction treatment. Produced by Centurion Laboratories in India, sildalis available in Australia for AUD $55-65 per 10 tablets.
How To Buy Cialis In Australia
In Australia, tadalafil is classified as a prescription-only medication (Schedule 4), meaning you must consult with a healthcare provider to obtain it legally. This evaluation includes discussion of your medical history, current medications, and any underlying conditions that might affect treatment safety. The brand cialis 20mg price in australia ranges from AUD $170-235 for 10 tablets, what is really expensive.
For those seeking cheaper prices with the same quality, generic online pharmacies offers generic cialis with price AUD $40-A$52 per 10 tablets without prescriptions with discreet packaging and home delivery services within 6-9 business days to major cities like Sydney, Melbourne, and Brisbane.
For those seeking cheap cialis australia options, daily-dose formulations (2.5mg or 5mg) often provide better value, with cialis 5mg price australia averaging around AUD $73.97 for a 30 pills supply.
Reviewed by: Dr Sharma - has published over 9 scientific articles, 23 publications and is a co-author of a textbook on medical urology education at UK universities for use in the educational process